Tsunade

Tsunade is the granddaughter of the First Hokage, Hashirama Senju, and grandniece of the Second Hokage, Tobirama Senju, leading others to call her "Princess" (姫, Hime). She, along with Jiraiya and Orochimaru are former students of the Third Hokage. Like Team Kakashi, Tsunade and her teammates were given the bell test. When Jiraiya lost and was tied to a log, she taunted him before leaving.
At some point, when she caught Jiraiya peeping on her while she was in the hot springs, she proceeded to break both of his arms, six of his ribs and ruptured several internal organs as a punishment for being a pervert. Ever since then, Jiraiya has been very careful to suppress his perverted ways around Tsunade. Jiraiya mentions that this is one of the two times he has ever been close to death.

During the Second Shinobi World War, Tsunade and her former team-mates fought Hanzō, who gave them the title of Konoha's "Three Legendary Shinobi" (伝説の三忍, Densetsu no Sannin) as a reward for surviving their battle.[3] On their way back to Konoha, they encountered the Ame Orphans, who Jiraiya chose to train. Throughout the war, she would become famous for frequently counteracting Chiyo's poisoning attempts, earning contempt from Chiyo because of it.[4] Furthermore, according to Jiraiya, Tsunade was the reason Konoha won the war.